Aduro Biotech Europe’s Chief Scientific Officer, Andrea Van Elsas, Ph.D. Featured as Keynote Speaker on Immunomodulatory Antibodies at ESMO Symposium on Immuno-Oncology 2015
November 20, 2015 at 08:00 AM EST
BERKELEY, Calif., Nov. 20, 2015 (GLOBE NEWSWIRE) -- Aduro Biotech, Inc. (Nasdaq:ADRO), a clinical-stage immunotherapy company, today announced the presentation of an overview of novel antibody and combination strategies designed to stimulate durable anti-tumor response at the European Society for Medical Oncology (ESMO) Symposium on Immuno-Oncology 2015, taking place November 20-21, 2015, in Lausanne, Switzerland. The presentation was featured in a keynote lecture delivered at the ESMO symposium by Andrea van Elsas, Ph.D., chief scientific officer of Aduro Biotech Europe, titled, “Immunomodulatory Antibodies Beyond PD-1.”
The presentation focused on advancements in the field of immuno-oncology involving combination antibody approaches targeting T cells (e.g. CD27 agonists), the tumor-immune interfaces (e.g. CD47 – SIRPα axis), dendritic cells and macrophages and bispecific antibodies. Dr. van Elsas also discussed promising early work with new agonists such as cyclic dinucleotides (CDNs).
“Recent advances in immunotherapy are bringing about a new era of cancer medicine and revolutionizing the development of novel treatments across a broad range of cancer types,” said Dr. van Elsas. “Checkpoint inhibitors have clearly demonstrated clinical benefit as single agent therapy in some patient populations, but emerging data suggests combination therapy may be required to extend this benefit to a majority of patients. At Aduro, our focus is on advancing multiple therapeutic approaches that have the potential to yield powerful immunotherapy combinations.”
During the presentation, Dr. van Elsas summarized the three diverse immunotherapy platforms that Aduro focuses on that aim to disrupt the tumor microenvironment and harness patients’ immune systems to fight multiple cancer targets:
Additionally, key topics that were highlighted in the presentation included:
Aduro believes this research underscores the critical importance of not only overcoming immune suppression, but also activating and stimulating the immune system using Aduro’s CDN approach targeting the STING receptor and Aduro’s LADD-based immunotherapies.
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