Blade Therapeutics Presents Analyses from Phase 1 and Preclinical Studies of Cudetaxestat at the European Respiratory Society International Congress 2022
September 04, 2022 at 08:00 AM EDT
Blade Therapeutics, Inc., a clinical-stage biopharmaceutical company developing cutting-edge treatments for debilitating fibrotic and neurodegenerative diseases, today announced the presentation of positive data from Phase 1 and preclinical studies of cudetaxestat, an investigational non-competitive autotaxin inhibitor in clinical development for IPF and other fibrotic diseases. The data were featured in a poster (abstract #PA459) presented today at the European Respiratory Society (ERS) International Congress 2022, which is taking place in Barcelona, Spain, from September 4-6, 2022.
"Cudetaxestat is a potential first-in-class, non-competitive autotaxin inhibitor with robust preclinical antifibrotic activity and good PK/PD correlations in Phase 1 clinical trials,” said Bassem Elmankabadi, M.D., senior vice president of clinical development with Blade and lead author of the poster. “The body of available data provides a strong rationale to move forward into Phase 2 clinical development of cudetaxestat in IPF, dosed either as monotherapy or concomitantly with approved therapies.”
The poster (click here for PDF), titled “Cudetaxestat, a differentiated phase 2-ready investigational treatment for idiopathic pulmonary fibrosis,” was presented in session TP-24: Interstitial lung diseases diagnosis in the COVID-19 era: new tools for new challenges. Data analyses were included from a battery of preclinical studies that assessed the potency and activity of cudetaxestat, and four Phase 1 studies of healthy volunteers (N=216) that evaluated safety/tolerability along with pharmacokinetic (PK) and pharmacodynamic (PD) activity.
Results of analyses from preclinical studies showed that cudetaxestat maintained potency against its target in vitro regardless of substrate (lysophosphatidylcholine, or “LPC”) concentration and demonstrated significant anti-fibrotic activity in multiple in vivo preclinical models. Across the phase 1 clinical studies, there were no drug-related serious adverse events (SAE’s), including in a study where cudetaxestat was dosed concomitantly with either of the approved therapies for IPF (nintedanib or pirfenidone). Based on available data, authors of the poster made the following conclusions:
For additional information about the ERS International Congress 2022, please visit the website.
About Blade Therapeutics
Blade Therapeutics presented data from Ph1 and preclinical studies of cudetaxestat, an investigational non-competitive autotaxin inhibitor in clinical development for IPF, at the European Respiratory Society International Congress 2022.